Research, all articles

Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy

05/12/2019

Perkin M, Logan K, Bahnson H, Marrs T et al. Background The Enquiring About Tolerance (EAT) study was a randomized trial of the early introduction of allergenic solids into the infant diet from 3 months of age. The intervention effect did not reach statistical significance in the intention...

Vitamin D Deficiency Is Associated With Impaired Muscle Strength And Physical Performance In Community-Dwelling Older Adults: Findings From The English Longitudinal Study Of Ageing

15/10/2019

Aspell N, Laird E, Healy M, Lawlor B, O'Sullivan M Purpose: Maintaining skeletal muscle function throughout life is a crucial component of successful ageing. Adequate vitamin D status may be important in preserving muscle function. We aimed to determine the association between impaired...

Could we be overlooking a potential choline crisis in the United Kingdom?

29/08/2019

Introduction Choline can be likened to omega-3 fatty acids in that it is an ‘essential’ nutrient that cannot be produced by the body in amounts needed for human requirements. The United States (US) Institute of Medicine (IOM)1 and European Food Safety Authority (EFSA)2 recognise that...

Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study

30/07/2019

ABSTRACT Background Moderate egg intake has been associated with better cognitive performance in observational studies. This association may be due to the rich content of choline, especially phosphatidylcholine, in eggs because choline has been suggested to have a role in the prevention of...

We still don’t know that our children need vitamin D daily: a study of parents’ understanding of vitamin D requirements in children aged 0-2 years

15/08/2019

Day R, Krishnarao R, Sahota P, Christian MS Abstract Background Vitamin D deficiency has been highlighted as a serious public health problem in the United Kingdom. One in four toddlers are not achieving the recommended intake for their healthy development. This study uses quantitative and...

Egg consumption and human health: an umbrella review of observational studies

05/08/2019

Abstract Egg consumption has been an area of controversy regarding its impact on human health largely due to the content in cholesterol and its potential role in cardio-metabolic outcomes. This study aimed to summarise the level of evidence of egg consumption on various health outcomes. A...

Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years

01/04/2019

Authors A. L. Darling, R. J. F. Manders, S. Sahni, K. Zhu, C. E. Hewitt, R. L. Prince, D. J. Millward, S. A. Lanham-New Abstract We undertook a systematic review and meta-analysis of published papers assessing dietary protein and bone health. We found little benefit of increasing protein...

WHO draft guidelines on dietary saturated and trans fatty acids: time for a new approach?

04/07/2019

The 2018 WHO draft guidance on fatty acids fails to consider the importance of the food matrix, argue Arne Astrup and colleagues. Key messages The 2018 WHO draft guidelines on dietary saturated fatty acids and trans fatty acids recommend reducing total intake of saturated fat and replacing...

Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations. Velazquez R, et al. Mol Psychiatry. 2019; Epub ahead of print.

08/01/2019

Abstract The lack of effective treatments for Alzheimer's disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades. Elevated homocysteine (Hcy) levels double the risk of developing AD. Choline, a...

Food-First Approach to Enhance the Regulation of Post-exercise Skeletal Muscle Protein Synthesis and Remodeling. Burd et al. Sports Med. 2019; 49(Suppl 1): 59–68.

22/01/2019

Abstract Protein recommendations are provided on a daily basis as defined by the recommended dietary allowance (RDA) at 0.80 g protein/kg/day. However, meal-based, as opposed to daily, dietary protein recommendations are likely more informative given the role of the daily protein...